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Sibutramine (si bue' tra meen) can be a beta-phenylethylamine that inhibits the synaptic reuptake of the two serotonin and norepinephrine. formulated to begin with as an antidepressant, it had little effect on depression, but its use was linked to fat loss that appeared to be due to lowered urge for food and minimized caloric consumption. Sibutrami